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ObjectivezzCircadian rhythm is cyclic variations in biological activity, which is crucial for physiology in mammals and alterations in circadian rhythm may be related to mood disorders. However, the effect of mood disorder medications on peripheral tissue is less understood. In this study, we investigated whether treatment with antidepressants, antipsychotics, and mood stabilizers in rat fibroblast influenced circadian rhythm. MethodszzLithium, bupropion, risperidone, lamotrigine, and paroxetine were used on cultured NIH3T3, peripheral rat fibroblast and we observed the periodic oscillation and rhythmicity of Per2, Bmal1 mRNA for 48 hours. ResultszzWe found that lithium has a dose-dependent effect on phase change of circadian rhythm and buproipion has a tendency to dampen the amplitude. Risperidone, lamotrigine, and paroxetine had no influence on circadian rhythm in NIH3T3 cell. ConclusionzzThese results suggest that lithium treatment may have an effect on circadian rhythm lengthening in peripheral fibroblast tissue.
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